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A brand new UConn find out about finds that tagatose, a plant-based sugar selection, presentations promise in mitigating Clostridioides difficile (C. difficile) an infection, specifically the ones proof against antibiotics. A pilot find out about carried out in a mouse fashion means that tagatose may be offering a singular nutraceutical strategy to wrestle this rising public fitness danger.
C. difficile is a number one reason behind hospital-acquired infections, with lines increasingly more displaying antibiotic resistance. Present remedies regularly contain broad-spectrum antibiotics, which is able to additional disrupt the intestine microbiome, exacerbating the an infection cycle. This has created an pressing want for selection methods.
The UConn find out about, led by means of Kumar Venkitanarayanan, Ph.D., affiliate dean for analysis and graduate research on the Faculty of Agriculture, Well being and Herbal Assets (CAHNR), investigated the impact of tagatose supplementation on C. difficile an infection in mice. The effects demonstrated that tagatose intake no longer simplest proved secure for animals but in addition considerably decreased an infection signs and severity.
“Our research indicates that tagatose has the potential to reduce C. difficile infection through multiple mechanisms,” says Venkitanarayanan. “Its prebiotic properties appear to promote a healthier gut microbiome, while preliminary evidence suggests it may also inhibit the production of bacterial toxins. This dual action could be particularly valuable in addressing antibiotic-resistant strains.”
Tagatose is a naturally going on monosaccharide present in small amounts in some culmination and grains. It’s roughly 92% as candy as sucrose however with a considerably decrease caloric worth and glycemic index. Tagatose has been FDA authorized for greater than two decades and is used as a low-calorie sweetener in more than a few meals merchandise. It additionally has NutraStrong prebiotic verified certification.
Bonumose, Inc., an enzyme answers corporate with a scalable procedure for generating high-purity, plant-based tagatose, is taking part with UConn and exploring the economic doable of UConn’s analysis.
The find out about was once carried out below a backed analysis settlement, which was once effectively negotiated with the beef up of UConn’s Generation Commercialization Products and services. Because of this collaboration, Bonumose lately holds an choice license to the generation.
“We are very excited about the outcomes of this sponsored research,” says Amit Kumar, Ph.D. “We believe these results will play a crucial role in advancing the development of this technology, bringing it closer to real-world impact.”
The UConn find out about provides to a rising frame of proof supporting the prebiotic and health-promoting houses of tagatose.
“The data from this UConn study supports what we already know about tagatose and gut health. Tagatose has the rare ability to not only feed good bacteria in the gut but to also inhibit the toxins produced by harmful bacteria,” says Karen Weikel, Ph.D., vp of regulatory & diet at Bonumose.
Additional analysis is deliberate to analyze the particular mechanisms of motion and to judge its efficacy in scientific trials.
“The affordability and accessibility of tagatose make it a promising candidate for a nutraceutical intervention. We are committed to exploring tagatose’s full potential in addressing C. difficile and other related health challenges. UConn’s research reinforces the significance of tagatose not only as a benign and delicious replacement for sugar in food production, but also as an ingredient with beneficial health effects,” Ed Rogers, Bonumose CEO.
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Publish date : 2025-02-25 06:56:05
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